Abstract
Clomiphene citrate resistance (CCR) occur in 15 - 40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates. Letrozole or gonadotropins use for ovulation induction in CCR is not well established which is superior and most safe.
Highlights
Clomiphene Citrate (CC) has been used as first line ovulation induction agent for 40 years ago [1,2]
Letrozole was superior to gonadotropin in clomiphene citrate resistant cases regarding ovulation and pregnancy rates with no effect on endometrial thickness
BMI was nearly similar in both groups with mean BMI 26.04 ± 4.33 in letrozole group compared to 27.01 ± 4.59 with no significant difference between both groups
Summary
Clomiphene Citrate (CC) has been used as first line ovulation induction agent for 40 years ago [1,2]. If ovulation not achieved by conventional dose (50 mg), dose is increased by 50 mg per day till we reach maximum dose (150 mg) [5]. Clomiphene citrate resistance is seen in approximately 15-40% in women with PCOS [7]. Clomiphene citrate resistance (CCR) occur in 15 - 40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates. Letrozole or gonadotropins use for ovulation induction in CCR is not well established which is superior and most safe
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