Abstract
Empiric ovarian stimulation with clomiphene citrate, aromatase inhibitors (Letrozole) or exogenous gonadotropin is commonly combined with IUI in the treatment of couples with unexplained infertility. The successful use of the aromatase inhibitor ,letrozole, for ovarian stimulation was documented when administered as a single dailydose or multiple daily fixed dose. To our knowledge,achieving consistent multifollicular development with letrozole, without the addition of FSH, has not been reported except in a retrospective rial (1)so this work was done to investigate success of a novel step-up protocol of letrozole as an attempt to achieve multifollicular development and to assess its effect on the outcome of IUI cycles in couples with unexplained infertility.
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