Abstract
Letrozole has been considered a potential strategy to improve IVF outcomes, as inhibition of cytochrome P450 aromatase enzyme activity would increase the levels of androgens by blocking their aromatization to estrogen. Letrozole may also improve ovarian response to FSH and be a potential tool for mild ovarian stimulation strategies. Although a positive effect of letrozole in lowering the total does of FSH, key IVF outcomes have not consistently been found to be significantly improved by the supplementation with letrozole.
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