Letrozole and Clomiphene on Endometrial Receptivity during Implantation in Mice

Abstract

The purpose of this article is to compare the effects of letrozole and clomiphene on the morphology of the endometrium during pre-ovulation and the receptivity of the endometrium during implantation. Discuss the superiority of letrozole over clomiphene for ovulation induction, and provide a theoretical basis for the clinical application of letrozole ovulation induction. The method of this article is to randomly divide 48 mice into 3 groups: letrozole group (n=16), clomiphene group (n=16) and control group (n=16). Pregnancy vibration after ovulation induction d=4.5 h to take the mouse uterus. Scanning electron microscope was used to observe the changes of endometrial pinocytosis and immunohistochemical technique to detect the expression of leukemia inhibitory factor in the endometrium. The results of the study showed that when the number of days of pregnancy in the three groups was the same, both the endometrial pinocytosis and the expression of Interleukin Enhancer Binding Factor in the letrozole group were similar to those in the control group. Among them, the pre-ovulation endometrial thickness in clomiphene group and control group were both 223.43±48.85, 239.66±68.93, while the letrozole group was 190.45±64.61, and the expression of letrozole group was significantly weaker than the previous two groups. Compared with clomiphene ovulation induction, letrozole did not affect the ultrastructure of the mouse endometrium during implantation and the expression of related genes interleukin enhancer binding factor, but the uterine receptivity of the clomiphene group showed a certain inhibitory effect.