Abstract
We were very interested to read the recent article by Wani et al.1 This study investigated the incidence of high-grade dysplasia (HGD) and esophageal adenocarcinoma in Barrett's esophagus (BE) with low-grade dysplasia (LGD). In contrast with previous studies that demonstrated the importance of LGD as a risk factor for neoplastic progression,2–5 the authors concluded that patients with BE and LGD had a low annual incidence of HGD/esophageal adenocarcinoma, which was not different from nondysplastic BE patients.
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