Lessons from SPRINT‐MIND on interventions to prevent dementia

Abstract

AbstractBackgroundThe Systolic Blood Pressure Intervention Trial (SPRINT) and the Systolic Blood Pressure Intervention Trial: Memory and cognition IN Decreased hypertension (SPRINT‐MIND) have contributed substantially to recent advances in the fields of hypertension, cardiovascular disease prevention, and prevention of cognitive decline.MethodRandomized clinical trial of 9,361 adults (mean age, 67.9 years) with hypertension and increased risk for cardiovascular disease with a mean follow‐up of 5.5 years. Participants were from diverse communities in the United States and were 27.8% black and 10.5% Hispanic.ResultSPRINT‐MIND has already demonstrated in this randomized trial that intensive blood pressure control significantly reduces the risk of incident overall mild cognitive impairment (HR, 0.81; 95% CI, 0.69‐0.95). However results related to subtype of MCI have not been released. This presentation will expand on findings related to intensive blood pressure control and the incidence of mild cognitive impairment (MCI) and Probable Dementia. The beneficial effect on MCI largely reflected in amnestic subtypes (HR, 0.78 [95% CI, 0.66‐0.92]) and multi‐domain MCI subtypes (HR, 0.78 [95% CI, 0.65‐0.93]), with no significant differences for non‐amnestic and single domain MCI subtypes. Data on the the mean scores each component of the cognitive battery according to adjudicated participant classification of 1) No impairment, 2) MCI or 3)Probable dementia will also be presented.ConclusionFindings from the SPRINT‐MIND trial continue to enhance understanding of the importance of cardiovascular disease prevention approaches as a pathway for also reducing the burden of cognitive impairment and dementia.