Abstract
Lessons from Reverse Translation.
Highlights
My project was to understand how one such minimally virulent clone evolved to cause tumors in some cats and an AIDS-like immunodeficiency in others
We found that the cellular gene contained within the viral genome functioned as a tumor-inducer, or oncogene
Whereas the tumor-causing feline leukemia virus (FeLV) made a rearranged version of a cellular gene, the AIDS-causing FeLVs entered cells by taking advantage of a protein encoded by a virus-like gene in the cat genome
Summary
My project was to understand how one such minimally virulent clone evolved to cause tumors in some cats and an AIDS-like immunodeficiency in others. OPEN ACCESS Citation: Lauring AS (2016) Lessons from Reverse Translation. By studying how viruses change their behavior, spread through communities, and make people sick, we end up learning a lot about how evolution works.
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