Lessons from Epidemiological Study of Acute Heart Failure Syndromes in Japan

Abstract

Acute heart failure (AHF) is a major public health concern because the number of AHF is increasing annually and high rate of readmission, although in-hospital mortality is not so high. To improve the managements for AHF, real-world patient characteristics and treatments should be clarified by an epidemiological study. Therefore, we conducted the registry for AHF, the ATTEND (acute decompensated heart failure syndromes) registry, enrolled 4842 patients. From the data from the ATTEND registry, mean age was 73 years and 58% were men. Sixty four percent of patients presented with de novo HF. Regarding in-hospital mortality, all cause and HF death were 6.4% and 3.9%, respectively. Many risk factors regarding in-hospital mortality, e.g., systolic blood pressure, heart rate, cool extremities, gender, anemia, and so on, were examined. Regarding treatments, furosemide and carperitide were used in 76% and 58% patients, respectively. Nitroglycerin and isosorbide dinitrate were administered in 15% and 21% patients, respectively. Dobutamine was most commonly used among inotropes, in 11% patients. Thus, the present study will reveal real-world AHF patient characteristics, treatments, and in-hospital mortality and then introduce important risk factors related to in-hospital mortality in AHF patients in Japan.