Abstract

Despite bile acid diarrhoea having a population prevalence of at least 1%, there are few studies on the condition that meet present day standards. Primary idiopathic bile acid diarrhoea accounts for around a third of patients who are investigated for chronic diarrhoea, although this diagnosis is often unrecognised. Treatment with bile acid sequestrants was first used more than 50 years ago in patients with bile acid diarrhoea after ileal resection.1 By binding bile acids in the intestine, these sequestrants reduce the adverse effects of bile acids on electrolyte and water absorption and motility in the colon.

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