Less reactive ketones as electrophiles and acrylamides as activated alkenes in intramolecular Baylis–Hillman reaction: facile synthesis of functionalized γ-lactam frameworks

Abstract

Less reactive ketones and acrylamides have been successfully employed as electrophiles and activated alkenes, respectively, in intramolecular Baylis–Hillman reaction, thus providing a facile protocol for obtaining functionalized α-methylene-γ-lactam derivatives.