Abstract
Les auteurs ont etudie le mecanisme de la toxicite de la primidone (Mysoline) chez certains microorganismes. Ces recherches montrent que le metabolisme de l'acide folique est inhibe par le primidone et cela en trois etapes: (a) la reduction de l'acide folique en acide dihydrofolique, (b) le metabolisme des pteridines nonconjugees et (c) la phosphorylation de la thymidine.
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