Abstract
We studied biopsies of gastric mucosa and the gastric antrum bodies obtained from 60 children with chronic gastritis and chronic gastritis in combination with chronic glomerulonephritis. Clinical data of patients (age, gender, duration of the underlying disease, conducted therapy, the results of laboratory and instrumental studies) were studied. It conducts research using histological and immunohistochemical methods. A morphological study of the sections found gastrobiopsies characteristic manifestations of chronic gastritis c signs of chlamydial lesions. The immunohistochemical method determined Chlamidia trachomatis antigens in the antrum and corpus. The positive expression in the epithelial cells of glands and endothelial microvascular gastric mucosa with concomitant lesions of the stomach and kidneys. The possibility of the development of chronic gastritis chlamydial infection in chronic glomerulonephritis. Based on the obtained results was made comprehensive assessment of the gastric mucosa based on morphological, immunohistochemical and clinical data. The features of stromal-vascular responses in the development of chronic gastritis occurring in isolation and combined with chronic glomerulonephritis. The effect of steroid therapy, as a cause of decrease in protective mechanisms of gastric mucosa in children. The data supporting the need for immunohistochemical studies for the etiologic diagnosis of chronic gastritis and the subsequent selection of appropriate therapy.
Highlights
Нами были изучены биоптаты из слизистой оболочки желудка антрального отдела и тела желудка, полученные при фиброгастродуоденоскопии от 60 детей с хроническим гастритом и в сочетании хронического гастрита с хроническим гломерулонефритом
We studied biopsies of gastric mucosa and the gastric antrum bodies obtained from 60 children with chronic gastritis and chronic gastritis in combination with chronic glomerulonephritis
The features of stromal-vascular responses in the development of chronic gastritis occurring in isolation and combined with chronic glomerulonephritis
Summary
Нами были изучены биоптаты из слизистой оболочки желудка антрального отдела и тела желудка, полученные при фиброгастродуоденоскопии от 60 детей с хроническим гастритом и в сочетании хронического гастрита с хроническим гломерулонефритом. Отмечена положительная экспрессия в эпителиоцитах желез и в эндотелиоцитах сосудов микроциркуляторного русла слизистой оболочки желудка при сочетанном поражении желудка и почек. Оценено влияние стероидной терапии как причина развития снижения защитных механизмов слизистой оболочки желудка у детей.
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