Lesion focused radiofrequency thermocoagulation of bottom-of-sulcus focal cortical dysplasia type IIb: Conceptional considerations with regard to the epileptogenic zone

Abstract

Small bottom-of-sulcus focal cortical dysplasias (BOS-FCD) type IIb are intrinsically epileptogenic lesions often responsible for pharmacoresistant epilepsy. They are increasingly well demarcated in vivo from surrounding cortex and white matter by 3 T magnetic resonance imaging (MRI). These facts and frequent seizure freedom after just narrow resections allow questioning the classical concept of epilepsy surgery in which the epileptogenic lesion is generally considered only one part of the epileptogenic zone and the resection volume categorically has to exceed lesion limits.This study approaches this question by analyzing procedures of strongly lesion focused stereotactic radiofrequency thermocoagulation (L-RFTC) applied to BOS-FCD IIb. Seven patients with BOS-FCD IIb were treated, three had invasive EEG recordings prior to L-RFTC, all had intraoperative stereotactic EEG-recordings. Perilesional epileptic discharges (PLD) were documented in all patients. Coagulation was planned based on MRI, the maximum extension beyond lesion limits due to PLD was 4.8 mm. Although in all patients other areas of PLD remained uncoagulated, seizure freedom was achieved in four of five patients with complete lesion coagulation.In summary, due to the minimal extensions of lesion coagulations, current experience with L-RFTC of BOS-FCD IIb is not yet sufficient to rebut the significance of PLD. It encourages, however, further research on even stronger MRI guidance and possibly even ignorance of PLD in BOS-FCD IIb. It appears possible that in some BOS-FCD IIB the complete epileptogenic zone (according to Lüders) might lie inside the MRI visible lesion. This would influence the understanding of the concept of cortical zones.