Leser-Trélat Sign With Porphyria Cutanea Tarda and Malignant Hepatoma

Abstract

To the Editor.— In the June 1975 issue of theArchives, Gitlin and Pirozzi 1 expressed a desire to stimulate comments regarding the Leser-Trelat sign. This prompts me to report a case in which the presence of eruptive seborrheic keratoses led to the search for an internal malignant neoplasm. Report of a Case.— A 72-year-old man was seen in June 1975; at the time, he had an 11-month history of blisters on the scalp and hands after minor trauma and a six-week history of itchy warts on the back and chest. In February 1974, an inguinal hernia on his left side was repaired; hepatomegaly was noted at that time. Physical examination in June 1975 showed eruptive seborrheic keratoses on the chest and back, milia on the dorsa of both hands, and bullae on the hands and forehead. The liver was enlarged 4 cm below the costal margin. A clinical diagnosis