Les substances antiglobulines humaines et anti-Gm dans le sérum des cancéreux

Abstract

Human anti-globulins in relation to the frequency of Gm (a), (b) and (x) groups were investigated in the serum of 1363 patients affected with malignant tumours, and 228 non-cancerous patients. They were found in 9·68% of patients with maligant tumours, and in 3·5% of non-cancerous patients. The incidence of anti-globulin agglutinators was higher among patients who underwent numerous transfusions (13·54%) than among non-transfused patients (5·73%). The frequency also increased in proportion to age (5·63%) before 50 years, 8·4% from 50 to 70 years and 11·66% after 70 years). Specific anti-Gm (a), (b) and (x) agglutinators were found in 21 sera ( 10 cases out of 57 transfused patients and 11 cases out of 54 non-transfused patients). They are most frequent among patients aged from 50 to 70 years, and less frequent after 70 years; they were not observed in patients under 50 years. The appearance of the antiglobulin factors as a consequence of an immunological process in cancerous patients is discussed by the authors.