Les réactions d’oxydation des protéines et leurs biomarqueurs

Abstract

The oxidation reaction corresponds to the action of reactive oxygen species and is responsible for the formation of advanced oxidation protein products, the main ones are methionine sulfoxide, dityrosine and 3-nitrotyrosine. These products are potential markers in Alzheimer’s disease or systemic lupus erythematosus. The oxidation reaction is also at the origin of the formation of reactive metabolites which are substrates for other reactions: carbonylation and non-enzymatic glycation. The main products formed during the carbonylation reaction, called advanced lipoxidation end products, are hydroxynonenal-lysine, malonic dialdehyde-lysine and carboxy-ethyl-lysine. During the non-enzymatic glycation reaction, the main products studied, called advanced glycation end products, are carboxymethyl-lysine and pentosidine, which constitute markers for the occurrence of adverse events in patients suffering from chronic diseases, like diabetes or kidney failure.