Abstract
Summary Fever of unknown origin (FUO) are defined by a fever greater than 38.3 °C evolving during at least 3 weeks and without diagnosis despite appropriate explorations. This clinical entity is not so uncommon. More than 200 causes of FUO have been reported. Despite medical advances, they remain unexplained in 10 to 30% of cases after exhaustive work-up. So FUO is a challenging medical problem. Clinical evaluation remains the basis of the initial evaluation of the patient with FUO. Newer diagnostic modalities, including blood chemistry, immunological tests and molecular methods have important role in the assessment of these patients. We will discuss in this review terminology, common causes of FUO and technical innovation.
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