Abstract
AbstractMalignant osteopetrosis in children is characterized by abnormal and excessive bone densification resulting from osteoclast dysfunction. It manifests itself, from the first months of life, by a repercussion on the skeleton, neurosensory disorders, orthodental anomalies, nervous system and hematopoiesis. Its diagnosis is based on clinical, radiological, biological and genetic criteria. The cytologist is involved in the diagnostic process by looking for quantitative abnormalities of the blood count and morphological abnormalities of the blood smear and the bone marrow aspiration. A serious and lethal disease, its treatment is based on hematopoietic cell transplantation.
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