Leptospirosis One of the Risk Factor for Kidney Diseases

Abstract

The disease leptospirosis is threatening both animals and humans. Leptospirosis can cause complications in multiple organs, including the kidneys early on, most often manifesting as tubulo-interstitial nephritis and tubular dysfunction. More than a million people are infected with leptospirosis every year, making it the most widespread zoonosis. Hotspots of leptospirosis and CKD are the agricultural intensive areas that are prone to flooding. Pallabi Pati Senior Research Fellow(SRF) Molecular Biology Division Regional Medical Research Centre(ICMR),Bhubaneswar. Lack of prompt treatment for acute leptospirosis can lead to chronic kidney damage and ultimately kidney failure. Because of the insidious nature for progression of CKD, the germs that cause it may be present in the kidney without causing any symptoms. Tubulointerstitial nephritis, interstitial fibrosis, and tubular atrophy are histologic findings of leptospirosis renal disease. Leptospirosis in adult male workers is associated with proximal tubule dysfunction, hypokalemia, and chronic kidney disease (CKD).