Leptospirosis in the Tropics: When Prevention Doesn’t Easily Sell as a Ton of Cure

Abstract

Problem statement: Human leptospirosis -- the most widespread zoonoti c disease -- thrives in tropical and subtropical climates. It is seldom addressed ex ante or prior to an outbreak or expected outbreak by governments of high-risk countries. Whether common, post-exposure treatment with antimicrobial drugs is more cost-efficient than red ucing animal reservoir populations was the overarching question that guided this study. A rel ated question in this study was how to establish comparability of pertinent price or cost estimates. Approach: Annualized price samples of government-approved, antimicrobial therapies and proposed rat and other rodent chemical agents (rodenticides) were gathered from three leptospiros is-endemic countries: Brazil, the Philippines and S ri Lanka. Certain price data were adjusted for present value based on a linear cost accounting function. Two-tailed hypothesis-testing ( α = 0.05) was performed to determine any statisticall y significant differences in pricing antimicrobial therapies and rodenticides in each country under investigation. Results: Shared socio-demographic characteristics of infect ed populations appear to support the need for ex ante containment of rat/rodent reservoir populations in tropical and subtropical countries. In each surveyed country, we found t crit >t obs >-tcrit . Therefore, the null hypothesis, � antimicrobial = � rodenticides = � antimicrobial - � rodenticides = 0, could not be rejected in favor of the alterna tive, � antimicrobial ≠ � rodenticides = � antimicrobial - � rodenticides ≠ 0. Conclusion: Applications of Price Estimation (PE) methods in f inancial economics, such as present value, help optimize hea lth decisions concerning zoonotic diseases. Leptospira transmission in Brazil, the Philippines and Sri La nka illuminate the need for broad and cohesive policies that take into account zoocentric measures. These may be critical in high-risk, tro pical and subtropical countries that periodically experie nce flooding, standing water and increased rainfall .