Leptomeningeal gliomatosis: A single institution retrospective study of 31 patients.

Abstract

e13017 Background: Secondary leptomeningeal gliomatosis (LMG) is a rare and severe progression pattern of glioma. Prognostic factors and therapeutic management of this pattern remains unclear. Our objective was to evaluate characteristics and outcome of LMG patients (pts). Methods: We retrospectively reviewed pts diagnosed with secondary LMG referred to our institution between 2004 and 2013. Diagnosis was obtained by clinical, imaging and cerebrospinal fluid (CSF) data. Results: The identification and diagnosis of 31 pts with LMG was based on CSF cytology (n=12), on MRI data (n=16) with hyperproteinarrachia (>1.2 gr/l) (n=9) or without (n=7), or on meningism with hyperproteinarrachia (n=3). At LMG diagnosis (LMGD), median age was 45 years and Karnofsky Performance Status (KPS) was <70 in 71% of pts; histological grade was IV in 20 pts and II-III in 11 pts. Median interval from initial glioma diagnosis (IGD) to LMGD was 13.5 months (glioblastoma: 8.1; grades II-III: 28.9). As first line therapy for LMG, 22...