Abstract
To the Editor: We were very glad to see the recent study by Wilkinson et al1 to show the leptomeningeal enhancement by head MRI. We agreed with authors that the enhancement was mainly over the leptomeninges and that the leakage of contrast medium resulted in this leptomeningeal enhancement. However, we did not think such leakage was due to injury of the blood-brain barrier. It would be more accurate to say that the contrast medium leaked out of the vessels associated with the subarachnoid space/pia mater. A physiologist unselectively termed “blood-brain barrier” as the interface between blood and brain; in a strict sense, the blood-brain barrier should exist within …
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