Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression.

Yunbao Pan,Tianhe Huang,Chenyan He,Yongchang Wei,Lingyun Hui,Fuling Zhou

doi:10.1155/2017/6482842

Yunbao Pan, Tianhe Huang + Show 4 more

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https://doi.org/10.1155/2017/6482842

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Abstract

Depression is the most common psychiatric disorder among cancer patients. Studies have not only highlighted that leptin and its receptor (LepRb) are independent poor prognostic factors in gastric cancer (GC) patients but also shown that the leptin-LepRb is necessary for antidepressant-like behaviors. In this study, we examined the serum and tissue leptin-LepRb expression in GC patients. Enzyme-linked immunosorbent assay showed that depressive GC patients had significantly higher serum leptin-LepRb than healthy donors. Leptin-LepRb levels in GC tissues were also significantly higher than in matched paracarcinoma tissues using real-time RT-PCR. Moreover, we observed that both serum and tissue leptin-LepRb were significantly higher in depressive GC patients than those in nondepressive GC patients. Further, the patients with high tumor stage tend to have higher leptin-LepRb mRNA levels than that with low tumor stage. Together, our findings suggest that leptin-LepRb plays an important role in the pathogenesis and depression in GC. Leptin-LepRb therefore could be a potential diagnostic marker and therapeutic target in GC patients with depression.

Highlights

Cancer is a difficult disease, affecting patients both physically and emotionally
To elicit the relationship between depression and gastric cancer (GC), we investigated the depression in 84 GC patients
The percent of patients in T3/T4 tumor stage in depressive cases was higher than that in nondepressive cases (77% versus 53%, P = 0.038, Fisher’s exact test) (Figure 1(a))

Summary

Introduction

Cancer is a difficult disease, affecting patients both physically and emotionally. Cancer is often considered synonymous with pain, suffering, and death. Cancer is a certain end but a permanent condition with delayed or late effects of the disease and concurrent psychological disorder [1]. Increased risk for psychiatric morbidity among cancer patients was reported [1, 2]. Depression has received increasing attention in cancer patients. Depression may be a part of the reaction to diagnosis, depression persists in many patients, creating difficulties in general management and therapy [3]. There is accumulating evidence indicating that affective and somatic depressive symptoms may occur prior to the establishment of a cancer diagnosis [4]. Depression prolonged hospital stays and decreased survival [5, 6]

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