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Abstract
Background: Leptin, a 160 kDa hormone produced and secreted by adipose tissue in direct relation to the amount of body fat. 1.9 billion adults have been identified as overweight and more than 650 million overweight adults are obese. Hyperleptinemia and resistance to reduction in body mass are two common characteristics of obesity. Methodology: A narrative review was carried out through various databases from January 2009 to November 2021; the search and selection of articles was carried out in journals indexed in English. Keywords were used: Leptin, obesity, appetite, anorexia. Results: Leptin has its main site of action in the brain, at the level of the brain stem and the hypothalamus. In order to modulate satiety and control of reward and aversion. As the amount of adipose tissue decreases, the amount of leptin produced that crosses the blood-brain barrier decreases. Conclusions: This review offers updated information on the association between Leptin and its role in the regulation of appetite and the development of obesity.
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