Abstract
Leptin supplementation in embryo culture medium increases in vivo implantation rates in mice
Highlights
Leptin, a metabolic hormone, regulates the reproductive functions responding to both nutritional and body condition [1]
Serum leptin levels vary during the menstrual cycle: the highest levels are observed in the preovulation period, while the lowest levels are seen in the luteal phase [4,5,6]
There was no significant difference in the inner cell mass (ICM) cell number between the leptin and control groups (P > 0.05)
Summary
A metabolic hormone, regulates the reproductive functions responding to both nutritional and body condition [1]. Previous studies revealed that supplementation of the embryo culture medium with leptin promoted the in vitro development of preimplantation mouse embryos, and markedly increased the total cell numbers [7,8]. Herrid et al [9] reported that the development rate of blastocyst significantly increased by media supplemented with 10 and 100 ng/mL, but not with 0.1 and 1 ng/mL of leptin, compared to the control group. Schulz et al [12] demonstrated that leptin had a role in the human trophoblast cell development and in the formation of placenta in early gestation
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