Abstract
Although testosterone deficiency (TD) can be present among 1 in 5 men 40 years or older, the factors responsible for TD remain largely unknown. Leydig cells produce testosterone in the testes under the pulsatile control of luteinizing hormone (LH) from pituitary gland. Leydig stem cells have the potential to differentiate into adult Leydig cells that can lead to increasing testosterone however the factors underlying reasons for differentiation remain unknown. In the present study we evaluated the paracrine factors released from testicular microenvironment (TME), which is comprised of Sertoli and peritubular myoid cells, in modulating differentiation of Leydig stem cells to Adult Leydig cells and production of Testosterone.
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