Abstract
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology.
Highlights
Specialty section: This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology
Obesity is typically characterized by excessive amounts of the hormone leptin, a cytokine-like molecule produced in white adipose tissue (WAT) that is secreted into the systemic circulation [4]
Leptin is released by adipocytes in proportion to the size of fat depots, enters the circulation, and reaches the central nervous system by crossing the blood-brain barrier (BBB) through receptor-mediated endocytosis [6] in which it acts mainly through the arcuate nucleus of the hypothalamus to mediate most of its actions [7]
Summary
Specialty section: This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology. Besides acting on the hypothalamus to suppress appetite, leptin induces lipolysis in WAT and thermogenesis in brown adipose tissue (BAT) and browning of WAT, via the activation of the sympathetic nervous system (SNS) [10].
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