Abstract
In the adult, circulating leptin concentrations are dependent on body fat content and on current nutrient intake. Whilst leptin concentrations in umbilical cord blood correlate with fetal adiposity in the human neonate, it is unknown whether leptin acts as a signal of fat mass before birth or whether changes in maternal nutrient intake alter plasma leptin concentrations in the fetus. We have therefore investigated the relationship between fetal plasma leptin concentrations and fetal fat mass in pregnant ewes fed at or above maintenance energy requirements.
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