Abstract
Object of research: to explore the relationship of leptin level in blood serum with markers of systemic inflammation and spontaneous production of cytokines and reactive oxygen species by blood mononuclear leukocytes at metabolic syndrome.Material and methods. We conducted a study of 50 patients with essential hypertension stage II in conjunction with the metabolic syndrome. Along with a complete clinical, laboratory and instrumental examination adopted in specialized cardiological clinic, were determined the concentration of markers of systemic inflammation and leptin in blood serum, as well as the relative abundance of the surface markers CD4+-, CD8+-lymphocytes and CD36+-monocytes, the level of spontaneous production of proand antiinflammatory cytokines and active oxygen species by blood mononuclear leukocytes.Results. It was found that patients with essential hypertension stage II with the MS having hyperleptinemia statistically significantly differ both as greater activity of systemic inflammation, and have a greater percentage of CD4+-lymphocytes and a higher level of spontaneous production of blood mononuclear leukocytes a number of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, MCP-1) and reactive oxygen species.
Highlights
We conducted a study of 50 patients with essential hypertension stage II in conjunction with the metabolic syndrome
Along with a complete clinical, laboratory and instrumental examination adopted in specialized cardiological clinic, were determined the concentration of markers of systemic inflammation and leptin in blood serum, as well as the relative abundance of the surface markers CD4+, CD8+-lymphocytes and CD36+-monocytes, the level of spontaneous production of pro- and antiinflammatory cytokines and active oxygen species by blood mononuclear leukocytes
ResultsIt was found that patients with essential hypertension stage II with the MS having hyperleptinemia statistically significantly differ both as greater activity of systemic inflammation, and have a greater percentage of CD4+-lymphocytes and a higher level of spontaneous production of blood mononuclear leukocytes a number of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, MCP-1) and reactive oxygen species
Summary
В амбулаторных условиях проведено одномоментное обследование 50 пациентов с гипертонической болезнью (ГБ) II стадии (артериальное давление (АД) менее 180/110 мм рт. ст.) [14] в сочетании с метаболическим синдромом, диагностированными согласно рекомендациям Всероссийского научного общества кардиологов [6]. Все участники исследования в зависимости от уровня лептинемии были разделены на две группы: 1-ю группу составили пациенты (12 человек) с нормативным уровнем концентрации лептина в сыворотке крови (для женщин не более 27,6 нг/мл и для мужчин не более 13,8 нг/мл), 2-ю группу составили пациенты (38 человек) с гиперлептинемией (более 27,6 и 13,8 нг/мл соответственно) [16]. Обнаружены статистически значимые различия по ряду показателей – маркеров МС (степени абдоминального ожирения, уровню систолического артериального давления (САД), концентрации инсулина и индексу HOMA-IR, характеризующему степень инсулинорезистентности, и концентрации СРБ). Сравнительный анализ клинико-лабораторных показателей в группах пациентов с разным уровнем концентрации лептина в сыворотке крови (Me (LQ; UQ)). Статистически значимые корреляционные взаимосвязи (r) между концентрацией лептина в сыворотке крови и клинико-лабораторными показателями МС, а также маркерами системного воспаления у больных ГБ
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