Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract.

Lan Xiang,Jianhua Qi,Kaiyue Sun,Minoru Yoshida,Qiaobei Wu,Jing Li,Lihong Cheng

doi:10.1155/2019/2935315

Abstract

Excessive food intake and metabolic disorder promote obesity and diabetes. In China, peanut skin is used as a herbal medicine to treat hemophilia, thrombocytopenic purpura, and hepatic hemorrhage. In the present study, we demonstrated that peanut skin extract (PSE) safely reduced appetite, body weight, fat tissue, plasma TG and TC, and blood glucose level in mice with diet-induced obesity (DIO). Moreover, the leptin/leptin receptor/neuropeptide Y (NPY) and adiponectin signaling pathways involved in the antiobesity effects of PSE are confirmed through leptin and adiponectin overexpression and leptin receptor silencing in mice. PSE consisted of oligosaccharide and polyphenol in a mass ratio of 45 : 55, and both parts were important for the antiobesity function of PSE. Our results suggested that PSE can be developed as functional medical food to treat metabolic disorders and obesity.

Highlights

As a global epidemic disease, obesity has become one of the greatest public health concerns of the 21st century [1]
After administrating peanut skin extract (PSE) with high-fat diet (HFD), the body weight gain (Figure 1(a)), food intake (Figure 1(b)), and water consumption (Figure 1(c)) of obese mice are significantly decreased compared with the HFD group at doses of 80 and 160 mg/kg (p < 0:01, p < 0:001)
These results suggest that PSE exhibits antiobesity effects for High-fat diet- (HFD-)induced obese mice

Summary

Introduction

As a global epidemic disease, obesity has become one of the greatest public health concerns of the 21st century [1]. In 2014, the World Health Organization estimated that more than 1.9 billion adults are overweight and over 600 million are obese [2]. Obesity strongly increases the risk factors for nonalcoholic fatty liver disease, type 2 diabetes, cardiovascular disease, and cancer [3]. All of these diseases severely influence the quality of life and shorten the lifespan of human [4, 5]. Most of the commercially available drugs show only marginal effects. The rebound after drug withdrawal and side effects of these drugs are considered the major problems. To overcome some of these limitations, we utilized safe functional foods and dietary regulation for obesity treatment

Methods

Results

Conclusion