Leptin, adiponectin levels, and thyroid hormones in normal and obese dogs

Abstract

Abstract : The present study compared leptin, adiponectin, and thyroid hormone concentrations in normal and obesedogs, and evaluated the association between leptin and adiponectin concentrations and thyroid function. The serumleptin, adiponectin, thyroid-stimulating hormone (TSH), total thyroxine (tT4), free thyroxine (fT4), triiodothyronine (T3),and cortisol concentrations were measured in 18 normal dogs (body condition score [BCS]: 4-5/9) and 16 obese dogs(BCS: 8-9/9). Leptin and T3 concentrations were higher in the obese group than the normal weight group (p <0.01and p < 0.05, respectively). In both groups, the T3 and leptin concentrations were correlated (r = 0.370, p < 0.05), aswere the TSH and fT4 and adiponectin concentrations (r = −0.373, p < 0.05 and r = 0.369, p < 0.05, respectively). Inthe normal weight group, the TSH and fT4 concentrations were correlated with the adiponectin concentrations (r = −0.528, p < 0.05 and r = 0.482, p < 0.05, respectively). The results of the present study suggest that leptin and T3concentrations are significantly higher in obese dogs than normal weight dogs, and the serum T3 and leptinconcentrations are positively correlated.Keywords : adiponectin, leptin, obese dog, thyroid hormones