Abstract
Introduction. Leptin as an adipose-tissue-related peptide hormone contributes to the control of food intake, energy expenditure, and other activities such as cell proliferation. Therefore, association of leptin level with thyroid cancer has been suggested recently. Considering that thyroid cancer is the most common endocrine cancer, the aim of this study was evaluation of leptin levels in thyroid cancer. Materials and Methods. 83 patients with papillary thyroid cancer (35 males and 48 females) with 90 healthy persons as control group (40 male and 50 females) were selected. serum thyroxine, thyrotropin, and leptin levels were determined in both groups. As a body fat tissue affects leptin level, so height and weight were measured and body mass index was calculated too. Results. There was no statistically significant difference in age, serum Thyroxine, and Thyrotropin levels. BMI in women was more than in men in both groups. Serum leptin levels in thyroid cancer group were significantly higher than control group (P < 0.05). Conclusion. The results of this study showed an acceptable association between the hormone Leptin levels with papillary thyroid cancer, so it may be considerad as a correlated peptide which may help in the diagnosis or confirmation of thyroid cancer beside in other specific tumor markers.
Highlights
Leptin as an adipose-tissue-related peptide hormone contributes to the control of food intake, energy expenditure, and other activities such as cell proliferation
Its level is proportional to the adipose tissue mass [2]. leptin as a neuroendocrine hormone has effects on the glucose metabolism, sexual maturation, reproduction, pituitary-adrenal axis, immune system, thyroid, and growth hormones level [3,4,5,6]
Since the leptin hormone secreted from adipose tissue is different in male and female, the different levels of measured leptin hormone in two groups are shown in Table 3
Summary
Leptin as an adipose-tissue-related peptide hormone contributes to the control of food intake, energy expenditure, and other activities such as cell proliferation. The results of this study showed an acceptable association between the hormone Leptin levels with papillary thyroid cancer, so it may be considerad as a correlated peptide which may help in the diagnosis or confirmation of thyroid cancer beside in other specific tumor markers. Leptin as a neuroendocrine hormone has effects on the glucose metabolism, sexual maturation, reproduction, pituitary-adrenal axis, immune system, thyroid, and growth hormones level [3,4,5,6]. The association between this neuroendocrine hormone with obesity and some cancers has been proposed. Studies have shown that leptin by increase of cell proliferation and inhibition of apoptosis is involved in creating certain types of tumors [17,18,19]
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