LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: a meta-analysis of 3,367 subjects.

Yan-Yan Li,Hyun Jun Kim,Xin-Xing Yang,Hui Wang,Jing-Jing Wu,Hong-Yu Geng,Lian-Sheng Wang,Zhi-Jian Yang

doi:10.18632/oncotarget.18720

Yan-Yan Li, Hyun Jun Kim + Show 6 more

Open Access

https://doi.org/10.18632/oncotarget.18720

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Journal: Oncotarget	Publication Date: Jun 27, 2017
Citations: 21	License type: cc-by

Affiliation: Jiangsu Province Hospital, University of Cincinnati

Abstract

BackgroundThe Leptin receptor (LEPR) Gln223Arg gene polymorphism has been associated with an increased susceptibility to Type 2 diabetes mellitus (T2DM). Results from various studies, however, are inconsistent.Objective and methodsTo better elucidate the association of LEPR Gln223Arg gene polymorphism with T2DM in the Chinese population, a meta-analysis of 3,367 subjects from seven independent studies was performed. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) were evaluated by the fixed-effects model.ResultsA significant relationship between LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population was found under allele (OR: 1.432, 95% CI: 1.211-1.694, P=2.67×10-5), dominant (OR: 1.466, 95% CI: 1.215-1.769, P=6.33×10-5), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06×10-4), and homozygous (OR: 0.472, 95% CI: 0.265-0.839, P=0.011) genetic models.ConclusionsLEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population. Therefore, Chinese carriers of the G allele of LEPR Gln223Arg gene polymorphism may be more susceptible to T2DM than the general population.

Highlights

The most recent survey from the Chinese Diabetes Society shows that the overall prevalence of diabetes mellitus (DM) has increased to 11.6% in the Chinese adult population, making the number of DM patients in China 114 million
A significant relationship between Leptin receptor (LEPR) Gln223Arg gene polymorphism and Type 2 diabetes mellitus (T2DM) in the Chinese population was found under allele (OR: 1.432, 95% 95% confidence intervals (CI): 1.211-1.694, P=2.67×10-5), dominant (OR: 1.466, 95% confidence intervals (95% CI): 1.215-1.769, P=6.33×105), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06×10-4), and homozygous (OR: 0.472, 95% CI: 0.2650.839, P=0.011) genetic models
LEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population

Summary

Introduction

The most recent survey from the Chinese Diabetes Society shows that the overall prevalence of diabetes mellitus (DM) has increased to 11.6% in the Chinese adult population, making the number of DM patients in China 114 million. Leptin is peptide hormone secreted by adipose tissue and while it is most famous as the mediator for the sensation of satiety, it helps regulate energy metabolism and body lipid homeostasis. It regulates insulin secretion through two distinct mechanisms.

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