Abstract
Leontopodic acid—a novel full substituted hexaric acid derivative, was isolated from the aerial parts of Edelweiss ( Leontopodium alpinum Cass.) as one of the major compounds. The complex structure of leontopodic acid-2-[(3 S)-3-hydroxybutanoate]-3,4,5-tris-[(2 E)-3-(3,4-dihydroxyphenyl)-2-propenoate]- d-glucaric acid—was elucidated by mass spectrometry, 1D- and 2D NMR spectroscopy and HPLC monitored transesterification. Leontopodic acid exhibited pronounced antioxidative effects in the Briggs-Rauscher (BR) model [(r.a.c.) m 3.4±0.5] and the trolox equivalent antioxidant capacity (TEAC) method (TEAC value of 1.53±0.11). The antioxidative properties of this compound were confirmed by the 3D method, an in vitro assay evaluating DNA protection against oxidative damage (IC 50: 1.89 μM).
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