Abstract
The lens concentrations of sodium and potassium were determined during galactose-induced cataractogenesis in 3 strains of albino rats. Four days after galactose feeding was initiated, lens potassium concentration decreased to 60% and sodium concentration increased to 175% of control values. In resistant, but not in susceptible, strains of animals partial return to control concentrations of both of these ions occurred. The changed lens sodium and potassium concentrations were maintained for 4-16 days depending on degree of resistance in each strain. Lens potassium then decreased and sodium concentration increased prior to actual opacification. The comparable weight gains of ad libitum fed animals of resistant and susceptible strains suggested that resistance or susceptibility to cataractogenesis resides in lens itself.
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