Abstract
The idea of regenerating injured body parts has captivated human imagination for centuries, and the topic still remains an area of extensive scientific research. This review focuses on the process of lens regeneration: its history, our current knowledge, and the questions that remain unanswered. By highlighting some of the milestones that have shaped our understanding of this phenomenon and the contributions of scientists who have dedicated their lives to investigating these questions, we explore how regeneration enquiry evolved into the science it is today, and how technological advances accelerated our understanding of these remarkable processes.
Highlights
It is through the eyes of the curious that we have begun to uncover one of the most amazing mysteries in biology: regeneration
In 1891 Colucci reported that newts were able to regenerate their ocular lenses upon removal even at adult stages; and in 1895 Wolff published his independent studies where he confirmed that the cellular source for this regeneration was the pigmented epithelial cells (PEC) of the iris (Wolff, 1895)
When newt dorsal irides were transplanted into lentectomized eyes of nonregenerating salamanders, they were able to form a lens, whereas regeneration did not take place if the transplantation was performed into the body cavity, suggesting that other extrinsic factors might influence the regenerative capacity of the tissue (Ikeda, 1934, 1935, 1936; Amano and Sato, 1940; Reyer, 1953, 1954, 1956; Stone, 1958a)
Summary
It is through the eyes of the curious that we have begun to uncover one of the most amazing mysteries in biology: regeneration. In 1891 Colucci reported that newts were able to regenerate their ocular lenses upon removal even at adult stages; and in 1895 Wolff published his independent studies where he confirmed that the cellular source for this regeneration was the pigmented epithelial cells (PEC) of the iris (Wolff, 1895).
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