Abstract

Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the association between leisure-time PA and dementia-related mortality differs according to level of psychological distress.Methods: 36,945 individuals from the Cohort of Norway aged 50-74 years at baseline (1994–2002) were included and followed up until January 1st 2015. Leisure-time PA and psychological distress were assessed through questionnaires, whereas dementia-related mortality was obtained through the Norwegian Cause of Death Registry. Adjusted Cox regression analyses were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI).Results: Compared to inactivity, leisure-time PA was associated with a decreased risk of dementia-related mortality; low intensity leisure-time PA (HR = 0.73, 95% CI 0.59–0.89); high intensity leisure-time PA (HR = 0.61, 95%CI 0.49-0.77). A statistically significant difference in dementia-related mortality risk was observed between low and high intensity leisure-time PA (p < 0.05). Psychological distress was associated with an increased risk of dementia-related mortality (HR = 1.45, 95% CI 1.16–1.81). Among non-distressed, leisure-time PA was associated with a decreased dementia-related mortality risk; low intensity leisure-time PA (HR = 0.77, 95% CI 0.61–0.97); high intensity leisure-time PA (HR = 0.65, 95% CI 0.51–0.84). The same applied for those with psychological distress; low intensity leisure-time PA (HR = 0.57, 95% CI 0.35–0.94); high intensity leisure-time PA (HR = 0.42, 95% CI 0.22–0.82). The interaction between leisure-time PA and psychological distress on dementia-related mortality was not statistically significant (p = 0.38).Conclusions: Participating in leisure-time PA was associated with a reduced risk of dementia-related mortality, whereas psychological distress was associated with an increased risk of dementia-related mortality. Leisure-time PA appears to be equally strongly related with dementia-related mortality among those with and without psychological distress, underlining the importance of leisure-time PA for various groups of middle-aged and older adults.

Highlights

  • Physical activity (PA) is widely considered one of the key lifestyle factors associated with reduced risk of mortality (Arem et al, 2015) and a number of non-communicable diseases (Reiner et al, 2013)

  • Leisure-time PA was associated with a decreased risk of dementia-related mortality when compared to inactivity; low intensity leisure-time PA (HR = 0.68, 95% confidence intervals (95% CI) 0.56–0.84); high intensity leisure-time PA (HR = 0.54, 95% CI 0.43–0.68) in a model adjusted by sex (Table 2, Model 1)

  • Psychological distress was associated with an increased risk of dementia-related mortality (HR = 1.45, 95% CI 1.16–1.81) in the fully adjusted model 3

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Summary

Introduction

Physical activity (PA) is widely considered one of the key lifestyle factors associated with reduced risk of mortality (Arem et al, 2015) and a number of non-communicable diseases (Reiner et al, 2013). A large body of research indicates that participating in regular PA may reduce the risk of cognitive decline (Blondell et al, 2014) and dementia (Rosness et al, 2014; Guure et al, 2017). Measures to prevent or delay new cases of dementia are required, and research on protective and risk factors for dementia has intensified during the last decade (Livingston et al, 2017). Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the association between leisure-time PA and dementia-related mortality differs according to level of psychological distress

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