Abstract
We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical cutaneous disease caused by Leishmania donovani parasites. L. donovani variants causing cutaneous manifestations in this region are different from those causing visceral leishmaniasis in northeastern India.
Highlights
We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India
In India, visceral leishmaniasis (VL) caused by L. donovani parasites in the northeastern region and cutaneous leishmaniasis (CL) caused by L. tropica in the western Thar Desert represent the prevalent forms of the disease [2]
Himachal Pradesh is a more recently leishmaniasis-endemic state in northwest where VL and CL coexist; CL incidence is higher than VL incidence and most cases are attributable to L. donovani instead of L. tropica infection [8,9]
Summary
An atypical insert of TAA and the fourth poly (A) isolates from Bhutan. An L. donovani Chandigarh microsatellite tract with 8 repeats; these polymor- isolate originally from HP is reported to be closest to phisms were identical to the VL-causing L. donovani the Bhutan isolates and matched with HP isolates at Figure 1. A) Multiple sequence alignment of ITS1 microsatellite repeat sequences of representative parasite isolates from CL patients with those of L. donovani complex reference strains from different geographic regions. Sequences were aligned by using BioEdit sequence alignment program (https://bioedit.software.informer.com/7.2). B) Phylogenetic tree of ITS1 sequences from CL test isolates (designated as HPCL, numbered in order of their collection) and standard Leishmania strains. Tree constructed by using maximum-likelihood method with 5,000 bootstraps in the dnaml program of PHYLIP package (http://evolution.genetics.washington.edu/phylip/doc/main.html).
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