Abstract
BackgroundLeiomyosarcomas of urinary bladder constitute rare malignant sarcomas with very few cases reported in literature.Case presentationHere, we present a case of bladder leiomyosarcoma in a well-preserved female. She failed to respond to standard chemotherapy and had a rapidly downhill course with unusual metastases in anastomotic site and peritoneum soon after surgery. Despite multimodality management including resection of primary and metastatic site, systemic therapy and pelvic radiotherapy, our patient had dismal prognosis with an overall survival of 1.7 years.ConclusionLeiomyosarcomas of bladder are aggressive tumors and have a very poor prognosis; thus, future research should focus on optimizing more effective treatment regimes.
Highlights
BackgroundPrimary leiomyosarcomas of bladder are rare but aggressive tumors with a median age of 52 years and a slight male preponderance
Leiomyosarcomas of urinary bladder constitute rare malignant sarcomas with very few cases reported in literature.Case presentation: Here, we present a case of bladder leiomyosarcoma in a well-preserved female
It is important to establish the difference between a variant urothelial histology vis-à-vis pure leiomyosarcoma for prognostication and treatment decisions
Summary
Primary leiomyosarcomas of bladder are rare but aggressive tumors with a median age of 52 years and a slight male preponderance. After 3 cycles, she had persistent symptoms and local progression on CECT, for which she received palliative radiotherapy to pelvis, 30 Gy in 10 fractions, and second line chemotherapy (gemcitabine 1000 mg/m2 days 1 and 8 + docetaxel 75 mg/ m2 day 1 every 3 weeks) for 6 cycles. She had recurrent hematuria, and imaging suggested progressive bladder growth and unchanged nodal disease (Fig. 1C, D). Within 6 weeks following surgery, she again presented to emergency with a progressive intraabdominal (left lumbar) soft
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