Leiomyosarcoma of the ovary in a young female guinea pig – a case report

Radka Lukášová,Miša Škorič,Eva Bártová

doi:10.2754/avb201786030269

Radka Lukášová, Miša Škorič + Show 1 more

Open Access

https://doi.org/10.2754/avb201786030269

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Abstract

This case report presents a one-year old pet female smooth-coated guinea pig with a diagnosis of leiomyosarcoma of the left ovary with locally aggressive behaviour. The animal had been showing lethargy and alopetic dermatosis for a few weeks. The mass in the area of the left ovary was suspected based on palpation, x-ray, ultrasonography of the abdominal cavity and the presence of the mass in the abdomen was confirmed by probatory laparotomy. Since the lesion was inoperable due to its size and infiltrative growth, the animal was euthanized. Leiomyosarcoma of the ovary with infiltrative growth into spleen and pancreas was diagnosed based on histopathological examination and the diagnosis was proved by immunohistochemical staining for the presence of smooth muscle actin. This is the first described case of this type of tumour in young intact female guinea pig. The case report could contribute to better understanding and knowledge of the occurrence of neoplastic changes of the ovary in guinea pigs especially for better treatment management and prevention of reproductive tract diseases.

Highlights

Sommerey et al (2004) proved that spontaneous tumours in general are relatively rare in guinea pigs (15% of 689 animals tested) with higher prevalence in older animals (39% of animals were > four years old)
Rivas et al (2014) suggested an origin of ovarian leiomyosarcoma from the smooth muscle of the blood vessels of the cortical stroma, as well as from the muscles around the corpus luteum and ovarian follicles, muscle fibres attached to the ovarian ligament, the remainder of Wolff’s duct, totipotent stem cells of the ovary, teratoma cells that have differentiated, or in smooth muscle cells that migrate from the uterus
The abdomen was opened in the region of linea alba with the finding of ascites and a large neoplasm (6 × 4 × 4 cm in size) on the left ovary intervening from the left uterus cranially under the left hepatic lobe (Plate IV, Fig. 2)

Summary

Introduction

Sommerey et al (2004) proved that spontaneous tumours in general are relatively rare in guinea pigs (15% of 689 animals tested) with higher prevalence in older animals (39% of animals were > four years old). A 13-month-old female smooth-coated guinea pig was presented to the Veterinary Clinic for Small Animals for alopecic skin lesions (Plate IV, Fig. 1). The infiltrative growth of the neoplasia into the muscles of the abdominal wall and caudal ribs and adhesions with the mesenterium and peritoneum were evident (Plate V, Fig. 3) Another finding was a nodular neoplasia at a size of 1 cm in diameter in the splenic ligamentum (Plate V, Fig. 4) and small cysts on the right ovary. Both the uterine bodies and the cervix uteri were hyperplastic. A proof of oestrogen and progesteron receptors could help specify the diagnosis of this type of tumour

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