Leiomyosarcoma and Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary.

Tip Pongsuvareeyakul,Somjet Chaicharoen,Surapan Khunamornpong,Kornkanok Sukpan

doi:10.1155/2017/7907359

Abstract

The occurrence of malignant transformation in mature cystic teratoma of the ovary is rare, with squamous cell carcinoma being the most common histologic type. Sarcomatous transformation has been rarely described in the literature. We present a case of leiomyosarcoma with a minor component of squamous cell carcinoma arising in mature cystic teratoma of ovary in a 65-year-old woman. The malignant tumor showed two distinct components of sarcomatous and invasive epithelial elements, which were confirmed by immunostaining. To our knowledge, only four cases of leiomyosarcoma in ovarian mature cystic teratoma have been reported and this is a unique case report of leiomyosarcoma and squamous cell carcinoma arising in a mature cystic teratoma of ovary.

Highlights

Mature cystic teratoma is the most common type of ovarian neoplasms, accounting for approximately 10%–20% of all ovarian tumors [1]
Only four cases of leiomyosarcoma arising in ovarian dermoid cyst have been described [3, 8, 13, 14]. In one of these cases, an associated component of squamous cell carcinoma in situ was present. We present another case of leiomyosarcoma arising in mature cystic teratoma of the ovary, with a coexisting minor component of squamous cell carcinoma
The diagnostic criteria for ovarian leiomyosarcoma are similar to those used for the uterine counterpart [17]

Summary

Introduction

Mature cystic teratoma (dermoid cyst) is the most common type of ovarian neoplasms, accounting for approximately 10%–20% of all ovarian tumors [1] It is a type of germ cell tumor of the ovary and may arise from postmeiotic primordial germ cells [2]. Only four cases of leiomyosarcoma arising in ovarian dermoid cyst have been described [3, 8, 13, 14] In one of these cases, an associated component of squamous cell carcinoma in situ was present. We present another case of leiomyosarcoma arising in mature cystic teratoma of the ovary, with a coexisting minor component of squamous cell carcinoma

Case Presentation

Findings

Discussion