Abstract
BackgroundDe novo malignancy is a severe complication after liver transplantation (LT), but de novo leiomyosarcoma is extremely rare. MethodsWe reported de novo leiomyosarcoma occurring after LT. The patient’s status for Epstein-Barr virus was negative. The donor was a 21-year-old man with a central nervous system malignancy who underwent surgery. Three months later brain death occurred and his organs were donated. ResultsLeiomyosarcoma in the recipient was detected shortly after LT. It progressed after minimization of immunosuppression and apatinib therapy, and the patient died of cachexia 17 months after LT. ConclusionsDe novo leiomyosarcoma is a rare but serious event after LT, needing comprehensive management.
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