Leiomyomatosis peritonealis disseminata (LPD): five case reports and review of the literature

Abstract

Purpose of investigation: Leiomyomatosis peritonealis disseminata (LPD) is a special type of leiomyomatosis with an unclear pathogenesis. Materials and Methods: The authors investigated five LPD patients who were treated at the Fudan University Shanghai Cancer Center (Shanghai, China) from 2012 to 2016. They reviewed the medical history, preoperative examination, intraoperative manifestation, and postoperative pathologic results. Results: The five LPD patients were all in reproductive age and four of them had a medical history of laparoscopy for uterine fibroids. Two of them had pathologic results of mitotically active leiomyoma. All the conditions may have contributed to the development of LPD. Conclusion: The use of laparoscopic power morcellation, active proliferative status of the uterine fibroids, and hormone in female patients may help cause LPD. The present study may improve our understanding of the disease.