Leiomyoma with Granulomatous Inflammation: Tissue Confirmation of Sarcoidosis

Kimi Verilhac,Miriam D Post,Jaime Arruda

doi:10.4236/ojog.2014.44029

Abstract

Granulomatous inflammation of the uterus is rare, and sarcoidosis involving the uterus is even less common. Sarcoidosis is an idiopathic granulomatous disease that can affect any organ, but most typically involves the lungs, lymph nodes, spleen, liver, skin, and eye. Although it can be diagnosed clinically based on a constellation of symptoms, definitive diagnosis typically requires demonstration of non-infectious non-caseating granulomas on tissue biopsy. It is a diagnosis of exclusion, and other causes of granulomatous inflammation must be excluded. We report here a case of granulomatous inflammation involving a leiomyoma in a patient with a previous clinical diagnosis of sarcoidosis. This was the patient’s first tissue-based diagnosis of sarcoidosis and highlighted the importance of adequate sampling of routine surgical specimens, as they may harbor signs of systemic disease.

Highlights

Sarcoidosis is a relatively rare disease, affecting approximately 10 - 71 per 100,000 people in the United States
The diagnosis can be made presumptively based on clinical features, definitive diagnosis requires a tissue specimen demonstrating non-caseating granulomas, where other etiologies for the
By the age of 50, leiomyomas are found in the uterus of almost 70% of white women and more than 80% of African American women [1]

Summary

Introduction

Sarcoidosis is a relatively rare disease, affecting approximately 10 - 71 per 100,000 people in the United States. It is usually sporadic and idiopathic, familial clustering has been reported. Women are affected more often than men and most commonly present between 20 and 40 years of age, often with a cough, fever, weight loss and chest pain. The diagnosis can be made presumptively based on clinical features, definitive diagnosis requires a tissue specimen demonstrating non-caseating granulomas, where other etiologies for the. How to cite this paper: Verilhac K., Arruda J. and Post M.D. (2014) Leiomyoma with Granulomatous Inflammation: Tissue Confirmation of Sarcoidosis. Open Journal of Obstetrics and Gynecology, 4, 177-181.

Report of a Case

Findings

Discussion