Abstract

Many advances have been made in understanding the role of transcription factors in different types of cancer. With colorectal cancer being the third most commonly diagnosed cancer, studying critical transcription factors such as the lymphoid enhancer factor/T-cell factor (LEF/TCF) transcription factor family may assist in understanding its growth and progression but also serve as a therapeutic target in hopes for better patient outcomes. This chapter will discuss the pathway LEF/TCF transcription factors are known to be involved in, their regulation, and current studies that have investigated their role and function in colorectal cancer and normal cell maintenance.

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