Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with potential cardiovascular involvement. The aim of this study was to assess left ventricular (LV) systolic function in a large cohort of patients with SLE using standard echocardiographic measurements and global longitudinal strain (GLS) by two-dimensional speckle-tracking analysis. Furthermore, the association between echocardiographic parameters and the occurrence of cardiovascular events was assessed. A total of 102 patients with SLE (88% women; mean age, 43±14years) undergoing a dedicated multidisciplinary assessment were analyzed, including echocardiography, at the time of their first visit. A control group consisted of 50 age- and sex-matched healthy subjects. Compared with control subjects, patients with SLE showed impaired LV systolic function on the basis of LV ejection fraction (51±6% vs 62±6%, P<.001) and by LV GLS (-15±3% vs -19±2%, P<.001). During a median follow-up period of 2years (interquartile range, 1-6years), 38 patients (37%) developed cardiovascular events. Kaplan-Meier survival curves showed that patients with SLE with more impaired LV GLS (on the basis of the median value of -15%) experienced higher cumulative rates of cardiovascular events compared with those with less impaired LV GLS (χ2=8.292, log-rank P=.004). On multivariate Cox regression analysis, LV GLS demonstrated an independent association with cardiovascular events (hazard ratio, 2.171; 95% CI, 1.015-4.642; P=.046), whereas LV ejection fraction was not significantly associated with the outcome. In patients with SLE, LV systolic function as measured by LV GLS is significantly impaired and associated with cardiovascular events, potentially representing a new tool to improve risk stratification in these patients.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with potential cardiovascular involvement
Pericarditis, and valvular disease was confirmed by baseline echocardiography (Table 2)
Mean SLE disease activity index (SLEDAI) was relatively high in the overall cohort
Summary
The aim of this study was to assess left ventricular (LV) systolic function in a large cohort of patients with SLE using standard echocardiographic measurements and global longitudinal strain (GLS) by two-dimensional speckle-tracking analysis. The purpose of the present study was to assess LV systolic function in a large cohort of patients with SLE using standard and advanced echocardiographic measurements, including LV GLS; in particular, the association between LV GLS and development of cardiovascular events was explored
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More From: Journal of the American Society of Echocardiography
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