Abstract
Summary A cardiac-tailored framework for 3D Diffusion Tensor MRI tractography is developed and used to characterize myofiber architecture in normal and remodeled myocardium. We show that myofibers in the subepicardium of the remote infarct zone become less oblique (more circumferential) as the heart dilates and remodels. This fiber realignment may play an important role in the loss of contractile function in the remote zone over time. Background
Highlights
Large infarctions cause the left ventricle (LV) to dilate and remodel, leading to a global decrease in LV function
We aim to characterize fiber architecture in the remote zone of remodeled hearts using a novel 3D cardiac-tailored diffusion MRI tractography framework that allows fibers in the entire heart to be evaluated as continuous entities
Myofibers were classified by their median helix angle (HA) and limited in length to half the LV circumference
Summary
Large infarctions cause the left ventricle (LV) to dilate and remodel, leading to a global decrease in LV function. While the impact of infarction on fiber architecture in the infarct zone is well understood, the impact of remodeling on fiber architecture in the remote zone is not. Diffusion Tensor Imaging (DTI) has contributed greatly to the study of cardiac structure and organization, but the majority of these studies employed 2D datasets [1,2]. We aim to characterize fiber architecture in the remote zone of remodeled hearts using a novel 3D cardiac-tailored diffusion MRI tractography framework that allows fibers in the entire heart to be evaluated as continuous entities. Fiber tracking was performed with a fourth-order Runge-Kutta approach. Myofibers were classified by their median helix angle (HA) and limited in length to half the LV circumference. Histograms of fiber HA were used to compare myofiber architecture in normal and remodeled myocardium
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