Left ventricular myocardial performance index in prediabetic patients without coronary artery disease

Abdulla Eliaw Mohamed Ali,Mohamed Alsenbesy,Hossam Eldin M Mahmoud,Gehad Osama Fawzy Sayed,Ahlam M Sabra

doi:10.1186/s43162-021-00063-y

Abdulla Eliaw Mohamed Ali, Mohamed Alsenbesy + Show 3 more

Open Access

https://doi.org/10.1186/s43162-021-00063-y

Copy DOI

Abstract

BackgroundPrediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders. Myocardial performance index (MPI) is a non-invasive Doppler method for the determination of global ventricular activity. We have not enough knowledge about the effect of prediabetes on the left ventricular (LV) function. We aimed to assess the MPI in prediabetic patients without coronary artery disease (CAD) utilizing echocardiography tissue Doppler imaging (TDI).ResultsWe conducted a randomized controlled study that included fifty prediabetic patients and fifty healthy participants as the control group. All the participants were subjected to laboratory tests and echocardiography TDI to evaluate the LV systolic and diastolic functionsWe found that the isovolumic relaxation time (IVRT) and MPI values were significantly increased in the prediabetic patients compared to the control group (P < 0.001). In contrast, left ventricular ejection time (ET) was significantly longer in the control group than in prediabetic patients.ConclusionPrediabetes may adversely affect the LV function as assessed by MPI. Screening for prediabetes and early intervention is required for the prevention of cardiovascular morbidity and mortality.

Highlights

Prediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders
The diagnosis of prediabetes was ensured according to the FPG level and/or OGTT results confirmed by repeating the tests on another day and/or measuring the Hemoglobin A1c (HbA1c) level based on American Diabetes Association (ADA) guidelines
Regarding the pretreatment laboratory profile, results showed that the mean of ALT, AST, S

Summary

Introduction

Prediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders. We aimed to assess the MPI in prediabetic patients without coronary artery disease (CAD) utilizing echocardiography tissue Doppler imaging (TDI). DM has a long-term effect on the cardiovascular system through microvascular and macrovascular complications. Myocardial injury in DM occurs due to coronary macrovascular and microvascular diseases, autonomic dysfunction, and diabetic cardiomyopathy. These physiopathological mechanisms often coexist and potentiate the effects of each. More than 200 million people are affected by type 2 DM throughout the world. It is estimated that 5–10% of prediabetic patients will progress to diabetes every year, and the same number of people will return to normoglycemia [3].

Objectives

Methods

Results

Discussion

Conclusion