Abstract
Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of subclinical LV dysfunction in patients with BD. 30 patients diagnosed as BD due to International Study Group Behcet's diagnostic criteria and 25 control subjects underwent Doppler echocardiography including pulsed tissue Doppler of the mitral annulus and speckle-tracking echocardiography. LV peak longitudinal strain and strain rate (SR) was calculated in four-chamber (4C), apical long-axis (LAX), and two-chamber (2C) views, and values of the three views were averaged LV global longitudinal strain (LV-GLS) and SR. LV torsion was determined as the net difference in the mean rotation between the apical and basal levels. There was not any significant difference in age and gender between groups. Patients with BD had significantly lower LV longitudinal strain and Sr measurements than the control group. Although LV basal rotation (LVR) basal values were similar in both groups, LVR-apical and LV torsion (LVTR) values were significantly higher in patient group. LVR-apical and LV-GLS were found to have a good positive corelation (r:0.44, p<0.001) (r: -0.56, r: -0.65,respectively. p<0.001). There was a weak positive correlation between LVTR and LV-GLS (r: 0.29, p<0.05). We demonstrated that combined assessment of LV-GLS, LV-GLSR, LVTR and LVR-apical values detected by STE can be useful in determination of subclinical left ventricular dysfunction in BD.
Highlights
Behcet’s disease is a multisystemic, vasculitic, chronic disorder characterized by recurrent oral aftous lesions, iridocyclitis with hypopyon and genital ulcers
There were not any significant differences in terms of age, gender, heart rate, left ventricular (LV) diastolic volume, LV systolic volume, LV ejection fraction (LVEF), left atrial (LA) and aorta diameters, while E (p = 0.001), Em (p = 0.001), Am (p = 0.004), S (p = 0.003) velocities were differed between the groups
LVS-4C (p = 0.001), LVS-2C (p = 0.001), LV global longitudinal strain (LV-GLS) (p = 0.001), LVSR-4C (p = 0.021), LVSR-L (p = 0.036) and LV global strain rate (LV-GLSR) (p = 0.001) values were found to be lower, while LV basal rotation (LVR)-apical (p = 0.001) and LV torsion (LVTR) (p = 0.001) values were significantly higher in patient group than in controls
Summary
Behcet’s disease is a multisystemic, vasculitic, chronic disorder characterized by recurrent oral aftous lesions, iridocyclitis with hypopyon and genital ulcers. Joint, central nervous, gastrointestinal, pulmonary and cardiovascular system involvement were reported in addition to the major findings of this disorder [1]. Cardiac involvement in BD is called as cardio-Behcet’s disease [2]. The mean age of the onset of the BD is most commonly the third decade, the final diagnosis is usually made in the fourth decade [3]. The incidence and nature of cardiac involvement in BD are not yet clearly documented.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
