Abstract
BackgroundCommon conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV). However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known.The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons.MethodsEchocardiography and Doppler was performed in a population-based sample aged 70 - The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 922).Hemodynamic patterns obtained by echocardiography and Doppler were evaluated in relation to four LV geometric groups (normal, concentric remodeling, eccentric hypertrophy and concentric hypertrophy).ResultsNo significant difference between the genders was observed regarding the prevalence of the LV geometric groups.Mean values of most evaluated echocardiography and Doppler variables differed between men and women, such as LA, IVS, LVEDD and IVRT, but the relationship of hemodynamic variables to LV geometric groups did not differ between the genders.ConclusionsAlthough mean values of many echocardiographic variables differed between men and women, the LV geometric adaptations to a given hemodynamic load appear similar in both genders.
Highlights
Common conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV)
Alteration of the left ventricle (LV) as a consequence of hypertension is a well known phenomenon and numerous studies have demonstrated that LV hypertrophy is a strong and independent predictor of cardiovascular events [1,2,3,4]
The echocardiographic measurements indicating different geometries such as interventricular septal thickness (IVS), posterior wall thickness (PW), LVEDD and LVESD were significantly larger in men (p < 0.0001) but on the other hand no significant difference could be demonstrated regarding relative wall thickness (RWT), left ventricular mass index (LVMI), CI or TPRI between men and women
Summary
Common conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV). Differences between the genders in the relationship of hemodynamics to LV geometry are not well known. Alteration of the left ventricle (LV) as a consequence of hypertension is a well known phenomenon and numerous studies have demonstrated that LV hypertrophy is a strong and independent predictor of cardiovascular events [1,2,3,4]. Different patterns of LV geometry as a result of hypertension were first described in a study by Ganau and coworkers in 1992 [10]. A 10-year follow-up of 253 persons with initially uncomplicated essential hypertension revealed that persons with concentric LV geometry had the highest risk for cardiovascular death (31%) and morbid events (11%). The lowest risk was observed in the group with normal LV geometry (no cardiovascular event and 11% risk for morbid events) [10]
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